無間の苦しみが人の世に降りかかる時。

When endless* suffering befalls the human world.

*[b]無間[/b] ([i]muken[/i], lit. without interval, interminable) is also an abbreviation for [b]無間地獄[/b] ([i]muken jigoku[/i]), the Buddhist Avici hell, the lowest and most painful of the eight hells. It is said that the previous seven hells are like a dream compared to Avici hell